Pei Zhou

Professor of Biochemistry

Protein-protein interactions play a pivotal role in the regulation of various cellular processes. The formation of higher order protein complexes is frequently accompanied by extensive structural remodeling of the individual components, varying from domain re-orientation to induced folding of unstructured elements. Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful tool for macromolecular structure determination in solution. It has the unique advantage of being capable of elucidating the dynamic behavior of proteins during the process of recognition. Recent advances in NMR techniques have enabled the study of significantly larger proteins and protein complexes. These innovations have also led to faster and more accurate structure determination. My research interests focus on the exploration of molecular recognition and conformation variability of protein complexes in crucial biomedical processes using state-of-the-art NMR techniques.

Appointments and Affiliations

  • Professor of Biochemistry
  • Professor of Chemistry
  • Member of the Duke Cancer Institute

Contact Information

  • Office Location: 270 Sands Building, Research Drive, Durham, NC 27710
  • Office Phone: (919) 668-6409
  • Email Address:


  • Ph.D. Harvard University , 1998
  • Harvard University , 2001

Courses Taught

  • BIOCHEM 393: Research Independent Study
  • BIOCHEM 593: Research Independent Study
  • BIOCHEM 659: Structural Biochemistry II
  • CBB 659: Structural Biochemistry II
  • CELLBIO 659: Structural Biochemistry II
  • SBB 659: Structural Biochemistry II
  • UPGEN 659: Structural Biochemistry II