Pei Zhou

Professor of Biochemistry

The Zhou lab focuses on the elucidation of the structure and dynamics of protein–protein and protein–ligand interactions and their functions in various cellular processes. Our current efforts are directed at enzymes and protein complexes involved in bacterial membrane biosynthesis, translesion DNA synthesis, co-transcriptional regulation, and host-pathogen interactions. Our investigations of these important cellular machineries have led to the development of novel antibiotics and cancer therapeutics, as well as the establishment of new biotechnology adventures.


The Zhou lab integrates a variety of biochemical and biophysical tools, including NMR, X-ray crystallography, cryo-EM, and enzymology. The lab has played a major role in the development and application of innovative NMR technologies, including high-resolution, high-dimensional spectral reconstruction techniques.

Appointments and Affiliations

  • Professor of Biochemistry
  • Professor of Chemistry
  • Member of the Duke Cancer Institute

Contact Information

  • Office Location: 270 Sands Building, Research Drive, Durham, NC 27710
  • Office Phone: +1 919 668 6409
  • Email Address:


  • Ph.D. Harvard University, 1998
  • Harvard University, 2001

Courses Taught

  • UPGEN 659: Structural Biochemistry II
  • SBB 659: Structural Biochemistry II
  • CELLBIO 659: Structural Biochemistry II
  • CBB 659: Structural Biochemistry II
  • BIOCHEM 659: Structural Biochemistry II
  • BIOCHEM 593: Research Independent Study
  • BIOCHEM 393: Research Independent Study